Direct pro-apoptotic role for NPM1 as a regulator of PIDDosome formation
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چکیده
منابع مشابه
NPM1 directs PIDDosome-dependent caspase-2 activation in the nucleolus
The PIDDosome (PIDD-RAIDD-caspase-2 complex) is considered to be the primary signaling platform for caspase-2 activation in response to genotoxic stress. Yet studies of PIDD-deficient mice show that caspase-2 activation can proceed in the absence of PIDD. Here we show that DNA damage induces the assembly of at least two distinct activation platforms for caspase-2: a cytoplasmic platform that is...
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Nitric oxide as a pro-apoptotic as well as anti-apoptotic modulator.
Nitric oxide (NO), synthesized from L-arginine by NO synthases, is a small, lipophilic, diffusible, highly reactive molecule with dichotomous regulatory roles in many biological events under physiological and pathological conditions. NO can promote apoptosis (pro-apoptosis) in some cells, whereas it inhibits apoptosis (anti-apoptosis) in other cells. This complexity is a consequence of the rate...
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15 صفحه اولA Role of Tec , a Non Receptor Tyrosine Kinase as Apoptotic Regulator
There are many types of tyrosine kinase involved in intracellular mitogenic mechanism, particularly, Tec tyrosine kinase are involved in apoptosis pathway. Tec tyrosine kinases do not have any transmembrane domain so it is known as non receptor tyrosine kinase. There are various types of Tec tyrosine kinase like Txk, Btk, Itk, Rik and Bmx. These kinases have different protein or domain structur...
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ژورنال
عنوان ژورنال: Molecular & Cellular Oncology
سال: 2017
ISSN: 2372-3556
DOI: 10.1080/23723556.2017.1348325